Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

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Population

Rat muscle acetylcholine receptor (AChR) channels (cDNA manipulation/expression models)

Comparison

Substitution of a threonine residue in the… vs Normal (wild-type) acetylcholine receptor channels

Design

Preclinical

Authors

Discussion

Animal data on AChR conductance require cautious interpretation; leaves open relevance to human channelopathies or therapeutics.

Population

Rat muscle acetylcholine receptor (AChR) channels (cDNA manipulation/expression models)

Intervention

Substitution of a threonine residue (alpha T264) in the alpha-subunit M2 transmembrane segment

Comparator

Normal (wild-type) acetylcholine receptor channels

Outcome

Channel conductance for alkali cations (Cs+, Rb+, K+, Na+)surrogate

The threonine residue at position 264 in the alpha-subunit of the AChR channel is a key determinant of ion flow and channel conductance.

Villarroel et al. (1991) studied this question.

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