Population
Simulated experiments of ion channel mechanisms (standard nicotinic receptor mechanism)
Design
Other
Authors
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Supports refined nicotinic receptor kinetic modeling from single recordings; leaves open extension to dependent sites or clinical translation.
The HJCFIT method allows robust estimation of ion channel rate constants from single channel recordings, though careful attention to parameter correlations and multiple likelihood solutions is required.
Colquhoun et al. (2003) studied this question.
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