Population
esterase-inactivated lizard intercostal neuromuscular junctions
Comparison
partial inactivation of acetylcholine receptors… vs normal endplates
Design
Preclinical
Authors
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These animal findings on receptor density effects warrant clinical caution; leaves open translation to human neuromuscular disorders.
In the normal neuromuscular junction, the most likely number of acetylcholine molecules needed to open an ion channel is 2, and the rise time is influenced by both density-dependent and independent factors.
Land et al. (1980) studied this question.