Why the study?
Does preexisting antibody to Norwalk virus protect against illness upon re-exposure?
Population
308 Massachusetts residents and a cohort of human volunteers inoculated with Norwalk virus
Design
Cohort
Authors
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Preexisting Norwalk antibody may not protect and could mark higher susceptibility; leaves open humoral immunity's role and needs prospective confirmation.
Does preexisting antibody to Norwalk virus protect against illness upon re-exposure?
Preexisting antibodies to Norwalk virus do not appear to confer immunity and may paradoxically be associated with higher susceptibility to illness upon re-exposure.
Blacklow et al. (1979) studied this question.
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