Computer-Aided Search for Effective Antisense RNA Target Sequences of the Human Immunodeficiency Virus Type 1

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Why the study?

Does the local folding potential of a target RNA sequence correlate with the effectiveness of antisense RNA against HIV-1?

Population

Genomic RNA and complementary RNA strand of the human immunodeficiency virus type 1 (HIV-1)

Design

Preclinical

Authors

Discussion

May guide antisense target selection for HIV-1; leaves open clinical translation pending human trials.

Does the local folding potential of a target RNA sequence correlate with the effectiveness of antisense RNA against HIV-1?

Population

Genomic RNA and complementary RNA strand of the human immunodeficiency virus type 1 (HIV-1)

Intervention

Computer-aided analysis of local folding potential (energy profile calculation using secondary structure prediction algorithm)

Outcome

Correlation between local folding potential (delta G values) and antisense RNA effectiveness (inhibition of HIV-1 replication)surrogate

Analysis of local folding potential can support the selection of effective target sequences for antisense RNA against HIV-1.

Sczakiel et al. (1993) studied this question.

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