July 1, 2002Journal of Biological ChemistryOpen Access

The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism

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Population

In vitro models studying cardiac-specific promoters and artificial reporter constructs

Design

Preclinical

Authors

YDYan‐Shan DaiBristol-Myers Squibb (United States)PCPeter CserjesiTulane University BMBruce E. MarkhamDiapin Therapeutics (United States)

Discussion

Member takes

Implication

Does not support clinical translation; leaves open whether targeting the GATA4-dHAND-p300 axis alters human cardiac development or disease.

Structured PICO

Population

In vitro models studying cardiac-specific promoters (atrial natriuretic factor, b-type natriuretic peptide, alpha-myosin heavy chain) and artificial reporter constructs

Intervention

Co-expression and interaction of transcription factors GATA4 and dHAND (HAND2)

Outcome

Activation of cardiac-specific promoters and physical interaction between GATA4, dHAND, and p300surrogate

The study identifies a physical interaction between GATA4 and dHAND that synergistically drives cardiac gene expression via a p300-dependent enhanceosome complex.

Cite This Study

Dai et al. (2002) studied this question.

synapsesocial.com/papers/6a700ba2ac440176ef28b291 https://doi.org/10.1074/jbc.m202490200

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Implication

Does not support clinical translation; leaves open whether targeting the GATA4-dHAND-p300 axis alters human cardiac development or disease.

The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider