Why the study?
Does higher serum PON1 activity predict a lower risk of coronary heart disease events in middle-aged men?
Population
1,353 men aged 49 to 65 years from the Caerphilly Prospective Study
Comparison
Highest quintile of serum PON1 activity toward… vs Lowest quintile of serum PON1 activity toward…
Design
Cohort
Follow-up
mean 15 years
Authors
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High PON1 activity was associated with lower CHD risk in men; leaves open causal role and clinical utility pending prospective validation.
Does higher serum PON1 activity predict a lower risk of coronary heart disease events in middle-aged men?
Low serum PON1 activity is an independent risk factor for coronary events, particularly in men at high risk due to preexisting disease or other risk factors.
Mackness et al. (2003) studied this question.
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