Effect of “Renal-Dose” Dopamine on Renal Function following Cardiac Surgery
Why the study?
Does prophylactic renal-dose dopamine improve renal function or prevent transient renal impairment in patients undergoing elective coronary artery bypass surgery?
Population
52 patients undergoing elective coronary artery bypass surgery
Comparison
Dopamine at 200 micrograms/min from induction… vs Placebo from induction for 24 hours
Design
RCT, prospectively randomised, double-blind
Follow-up
24 hours
Authors
Discussion
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Implication
Prophylactic renal-dose dopamine should not be used routinely in elective CABG; this RCT confirms it confers no renal protection.
Structured PICO
Does prophylactic renal-dose dopamine improve renal function or prevent transient renal impairment in patients undergoing elective coronary artery bypass surgery?
P
Population
52 patients undergoing elective coronary artery bypass surgery
I
Intervention
Dopamine at 200 micrograms/min from induction for 24 hours
C
Comparator
Placebo from induction for 24 hours
O
Outcome
Renal function (urine output, creatinine clearance, free-water clearance) and incidence of transient renal impairment at 24 hourssurrogate
Routine prophylactic renal-dose dopamine does not improve renal function or prevent transient renal impairment in patients undergoing elective coronary artery bypass surgery.
Cite This Study
Myles et al. (1993) studied this question.