Why the study?
Does dopamine infusion improve renal function compared to maintaining perfusion pressure >70 mm Hg with phenylephrine in patients with preoperative abnormal renal function undergoing elective coronary surgery?
Does dopamine infusion improve renal function compared to maintaining perfusion pressure >70 mm Hg with phenylephrine in patients with preoperative abnormal renal function undergoing elective coronary surgery?
In patients with baseline renal impairment undergoing coronary surgery, dopamine infusion partially reverses renal vasoconstriction before CPB but provides no clinically relevant renal protection during or after CPB compared to maintaining perfusion pressure with phenylephrine.
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Dopamine confers no clinically relevant renal protection versus phenylephrine during or after CPB; challenges its routine use for this purpose in coronary surgery patients with baseline impairment.
Lema et al. (1998) studied this question.
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