Key result
Population apo E allele distribution tracks geographic coronary heart disease mortality rates.
Cross-Sectional
Yes
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The distribution of apolipoprotein E (apo E) polymorphism was examined in 11 population groups not previously studied for this system. There is a marked difference in phenotype and gene frequency between the populations of England and Spain. The south European populations of Basques and Spanish non-Basques showed greater similarity to the populations of South Asia. The study clearly indicates that the distribution of apo E alleles does match with regions showing a high mortality rate of coronary heart disease. The data presented also indicate that authochthon groups such as Basques in Europe and tribals in India may throw better light on the role of apolipoproteins in the regulation of lipid levels in disease.
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Mastana et al. (1998) conducted a cross-sectional in Apolipoprotein E polymorphism and coronary heart disease risk. Apolipoprotein E (apo E) polymorphism vs. Other populations was evaluated on Phenotype and gene frequency of apo E alleles. The distribution of apo E alleles, including a low frequency of the apo E4 allele in Basques and Indian tribal populations, matches regions with high coronary heart disease mortality.
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