What question did this study set out to answer?

The study aims to analyze the effects of different anesthetics on central hemodynamics in spontaneously hypertensive and Wistar-Kyoto rats.

April 1, 1980AJP Heart and Circulatory Physiology

Anesthetic effects on hemodynamics of spontaneously hypertensive and Wistar-Kyoto rats

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Why the study?

Do different anesthetic agents alter central hemodynamics in spontaneously hypertensive and Wistar-Kyoto rats compared to their conscious state?

Population

Spontaneously hypertensive and Wistar-Kyoto rats instrumented with chronic electromagnetic flow probes and…

Comparison

Three anesthetic agents: ether, pentobarbital… vs Conscious state

Design

Preclinical

Authors

TSThomas L. SmithWake Forest University PHPhillip M. HutchinsAtrium Health Wake Forest Baptist

Discussion

Member takes

Implication

Anesthetics may confound hemodynamic readouts in hypertensive rat models; leaves open optimal agent selection for future translational studies.

Key Points

The study aims to analyze the effects of different anesthetics on central hemodynamics in spontaneously hypertensive and Wistar-Kyoto rats.
Rats instrumented with chronic electromagnetic flow probes and arterial pressure catheters
Three anesthetic agents tested: ether, pentobarbital sodium, chloralose-urethane mixture
Central hemodynamic parameters measured and compared between SHR and WKY populations.
Ether significantly increased heart rate and cardiac index in SHRs (P<0.01) and WKYs (P<0.05).
Pentobarbital sodium decreased heart rate, cardiac index, and mean arterial pressure in both rat types (P<0.05--P<0.001).
Chloralose-urethane mixture had effects similar to pentobarbital but did not change heart rate or total peripheral resistance.

Structured PICO

Do different anesthetic agents alter central hemodynamics in spontaneously hypertensive and Wistar-Kyoto rats compared to their conscious state?

Population

Spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats instrumented with chronic electromagnetic flow probes and arterial pressure catheters

Intervention

Three anesthetic agents: ether, pentobarbital sodium (PBS; 50 mg/kg), and a 2% chloralose-7.5% urethan mixture (CU; 6 ml/kg)

Comparator

Conscious state (baseline hemodynamics of conscious rats)

Outcome

Central hemodynamics including heart rate (HR), cardiac index (CI), stroke volume (SV), peak aortic flow velocity (PAFV), total peripheral resistance (TPR), mean arterial pressure (MAP), and minute work (MW)surrogate

Anesthetic agents significantly and differentially alter central hemodynamics in spontaneously hypertensive and normotensive rats compared to the conscious state, highlighting the need to consider anesthetic effects in cardiovascular research.

Cite This Study

Smith et al. (1980) studied this question.

synapsesocial.com/papers/6a70102a2163a0a01bc4470a https://doi.org/10.1152/ajpheart.1980.238.4.h539

Topics

Hypertension management

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Implication

Anesthetics may confound hemodynamic readouts in hypertensive rat models; leaves open optimal agent selection for future translational studies.

Anesthetic effects on hemodynamics of spontaneously hypertensive and Wistar-Kyoto rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Anesthetic effects on hemodynamics of spontaneously hypertensive and Wistar-Kyoto rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider