June 2, 2004Human Molecular GeneticsOpen Access

Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II

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Population

24 UK familial combined hyperlipidemia probands and healthy young men from the European Atherosclerosis…

Comparison

USF1 gene variations vs Different USF1 genotypes/haplotypes

Design

Case-control

Authors

WPW. PuttUniversity College London JPJutta PalmenUniversity College London VNViviane NicaudUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

USF1 variants may link to glucose-lipid traits in young men; hypothesis-generating for gene-BMI interactions and needs replication before any clinical use.

Structured PICO

Population

24 UK familial combined hyperlipidemia (FCHL) probands and healthy young men (cases and controls) from the European Atherosclerosis Research Study II offspring study

Intervention

USF1 gene variations (SNPs 306A>G, 475C>T, 1748C>T and haplotypes)

Comparator

Different USF1 genotypes/haplotypes

Outcome

Fasting and postprandial lipids, and glucose parameters after an oral glucose tolerance test (OGTT)surrogate

Variation in the USF1 gene influences both glucose and lipid homeostasis, showing significant gene-environment and gene-gene interactions in healthy young men.

Cite This Study

Putt et al. (2004) studied this question.

synapsesocial.com/papers/6a70119331a3df8243285911 https://doi.org/10.1093/hmg/ddh168

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Implication

USF1 variants may link to glucose-lipid traits in young men; hypothesis-generating for gene-BMI interactions and needs replication before any clinical use.

Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider