Why the study?
What is the prevalence of mutant LPL alleles in French Canadian patients with hypertriglyceridemia compared to normotriglyceridemic controls?
Population
310 French Canadian subjects, including 95 with type IV hyperlipoproteinemia, 26 with type V HLP, 39 with…
Comparison
Assessment of four mutant lipoprotein lipase… vs Normotriglyceridemic controls
Design
Cross-sectional
Authors
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LPL heterozygosity was associated with type IV/V hyperlipoproteinemia in French Canadians; leaves open causal contribution and need for prospective validation.
What is the prevalence of mutant LPL alleles in French Canadian patients with hypertriglyceridemia compared to normotriglyceridemic controls?
In French Canadians, 15-20% of type IV and V hyperlipoproteinemia cases are associated with specific genetic defects in plasma triglyceride catabolism.
Minnich et al. (1995) studied this question.
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