March 1, 1989Journal of Clinical InvestigationOpen Access

Chronic exercise training protects aged cardiac muscle against hypoxia.

View Full Paper

Ask AI

Bookmark

Why the study?

Does chronic exercise training improve tolerance to hypoxia in aged and young adult rat hearts?

Structured PICO

Does chronic exercise training improve tolerance to hypoxia in aged and young adult rat hearts?

Population

Young adult (9 mo) and old (24-26 mo) male Fischer 344 rats

Intervention

Chronic exercise on a rodent treadmill

Comparator

Age-matched, nonexercised controls

Outcome

Cardiac function during hypoxia (maximum developed tension, maximum rate of tension development, maximum rate of tension decline, and time required for hypoxia to reduce maximum tension by 20%)surrogate

Chronic exercise preserves both contraction and relaxation during hypoxia in both aged and young adult rat hearts.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Chronic exercise may preserve hypoxic tolerance in rat hearts; leaves open translation to human aging or clinical hypoxia.

Cite This Study

Wei et al. (1989) studied this question.

synapsesocial.com/papers/6a701203ac440176ef28b767 https://doi.org/10.1172/jci113957

View Full Paper

Ask AI

Bookmark

Chronic exercise training protects aged cardiac muscle against hypoxia.

Structured PICO

Discussion

Implication

Cite This Study

Chronic exercise training protects aged cardiac muscle against hypoxia.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider