Why the study?
It was unknown whether Dahl salt-resistant rats are protected against hypertension during diet-induced obesity, given their protection after high-salt or high-fructose intake.
Does a high-fat diet induce hypertension in Dahl salt-resistant rats compared to Dahl salt-sensitive rats?
Does a high-fat diet induce hypertension in Dahl salt-resistant rats compared to Dahl salt-sensitive rats?
Dahl salt-resistant rats are protected against hypertension during diet-induced obesity, implying a shared genetic trait determining salt, fructose, and fat sensitivity.
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Animal data suggest genetic resistance to obesity-induced hypertension; leaves open translation to human dietary interventions.
Lee et al. (2022) studied this question.
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