Why the study?
Does left atrial appendage invagination improve atrial flow fields and reduce the risk of thrombus formation in a computational model of atrial fibrillation?
Does left atrial appendage invagination improve atrial flow fields and reduce the risk of thrombus formation in a computational model of atrial fibrillation?
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Computational modeling suggests that LAA invagination may reduce thrombus risk in atrial fibrillation by eliminating blood stasis and low shear rates.
Invagination is an innovative technique for closing the left atrial appendage (LAA) to reduce the risk of thrombi formation. The influence of LAA invagination on the flow fields in the atria was investigated based on a computational fluid dynamics. The simulation results demonstrated that the novel invagination process can eliminate low velocities (blood stasis) and low shear rate and thus decrease the risk of thrombus formation during atrial fibrillation. This innovative technique may enhance the clinical treatment of patients with atrial fibrillation by improving the atrial flow field while lowering the risk of creating emboli.
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Hazan et al. (2018) studied this question.
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