Population
Smooth muscle heavy meromyosin C-loop chimeras and wild-type
Comparison
Substitution of native C-loop with skeletal and… vs Wild-type smooth muscle heavy meromyosin
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether C-loop targeting could modulate myosin function in cardiomyopathy.
The study provides basic science evidence that the myosin C-loop functions as an allosteric actin contact sensor essential for maximal myosin activation.
Ajtai et al. (2009) studied this question.
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