Why the study?
Does the ACE2 rs2106809 T allele increase the risk of hypertension and alter the antihypertensive response to ACE inhibitors in women?
Population
3,408 untreated hypertensive patients and participants in two independent case-control studies
Comparison
Atenolol, Hydrochlorothiazide, Captopril, or… vs ACE2 CC genotype carriers and non-hypertensive…
Design
Other, Randomized to Atenolol, Hydrochlorothiazide, Captopril, or Nifedipine…
Follow-up
4 weeks
Authors
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May inform genotype-guided hypertension management in women; extends pharmacogenomic evidence for ACE2 variants and ACE inhibitor response.
Does the ACE2 rs2106809 T allele increase the risk of hypertension and alter the antihypertensive response to ACE inhibitors in women?
The ACE2 rs2106809 T allele is associated with an increased risk of essential hypertension in women and a blunted diastolic blood pressure response to captopril.
Fan et al. (2007) studied this question.
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