Why the study?
Does the ACE gene I/D polymorphism influence the long-term risk of major adverse cardiac events in patients with symptomatic coronary artery disease undergoing percutaneous coronary intervention?
Population
1010 patients with symptomatic coronary artery disease who underwent successful coronary stent placement
Comparison
Presence of one or two D alleles of the… vs ACE gene II genotype
Design
Cohort
Follow-up
median two years
Authors
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ACE I/D genotyping does not aid risk stratification after PCI; hypothesis-generating for other genetic markers in CAD prognosis.
Does the ACE gene I/D polymorphism influence the long-term risk of major adverse cardiac events in patients with symptomatic coronary artery disease undergoing percutaneous coronary intervention?
The ACE I/D gene polymorphism does not predict long-term major adverse cardiac events in patients undergoing percutaneous coronary intervention, suggesting genetic screening for this polymorphism is not useful for secondary prevention.
M. Hamon (2003) studied this question.
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