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June 18, 2018Journal of NeurologyOpen Access

Depressive symptoms in stroke patients treated and non-treated with intravenous thrombolytic therapy: a 1-year follow-up study

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Why the study?

Does intravenous thrombolytic therapy reduce post-stroke depression in stroke survivors?

Population

146 stroke survivors (73 thrombolysed and 73 non-thrombolysed matched for age and gender)

Comparison

Intravenous thrombolytic therapy (rt-PA) vs Non-thrombolytic treatment

Design

Cohort

Follow-up

12 months

Authors

BGBarbara Grabowska-FudalaPoznan University of Medical SciencesKJKrystyna JaraczPoznan University of Medical SciencesKGKrystyna GórnaPoznan University of Medical Sciences

Discussion

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Overview

Supports PSD assessment post-thrombolysis; leaves open whether thrombolysis independently influences depression risk.

Structured PICO

Does intravenous thrombolytic therapy reduce post-stroke depression in stroke survivors?

P
Population
146 stroke survivors (73 thrombolysed and 73 non-thrombolysed matched for age and gender)
I
Intervention
Intravenous thrombolytic therapy (rt-PA)
C
Comparator
Non-thrombolytic treatment
O
Outcome
Frequency of post-stroke depression (PSD) assessed using the Beck Depression Inventory at 3 and 12 monthspatient reported

Intravenous thrombolysis may have an indirect positive effect on mood in the first months after stroke, despite similar unadjusted frequencies of depressive symptoms compared to non-thrombolysed patients.

Limitations

  • Use of a questionnaire for the detection of depression
  • Relatively small sample size
  • Significant drop-out rate

Cite This Study

Grabowska-Fudala et al. (2018) studied this question.

synapsesocial.com/papers/6a7018f85671bbf00bc2a3e4https://doi.org/10.1007/s00415-018-8938-0
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic posttraumatic stress symptoms after nonsevere stroke2006 · 130 citations
  2. 2An Inventory for Measuring Depression1961 · 38,437 citations
  3. 3The functional basis of counterfactual thinking.1994 · 689 citations
  4. 4Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial2013 · 157 citations