Population
Guinea pigs with allergic encephalomyelitis (AE) and rats
Comparison
Exposure to adult rat nervous tissue vs Exposure to neonatal rat nervous tissue
Design
Preclinical
Authors
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Supports antigen-specific cellular hypersensitivity in AE pathogenesis; leaves open translation to human demyelinating disease.
Cells from animals with allergic encephalomyelitis display hypersensitivity directed specifically to the encephalitogenic antigen, supporting their role in the disease's pathogenesis.
David et al. (1965) studied this question.
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