Incubation with myelin basic protein enables the transfer of experimental allergic encephalomyelitis using a relatively small number (10^7) of guinea pig peritoneal exudate cells, facilitating in vitro immunologic studies.
May enable efficient in vitro EAE studies; leaves open extension to human CNS autoimmunity models.
Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10(7) cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible.
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Driscoll et al. (1979) studied this question.
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