Changes in Cellular Proteins During Chemically‐induced Tumour Formation in the Liver

Summary Evidence is presented that in the malignant cell of rat liver tumours a highly specific cellular protein has either been lost or has been modified; this is judged by the cell's control the growth of tissues and organs and, in ordinary circumstances, limit the proliferation of tissue cells. The significance of these observations in human neoplasms is as yet uncertain. However, this is being studied and if the staining technique should prove applicable it will be not only a valuable method of investigating tumours but possibly also important in differentiating tumour‐like masses from true neo‐plasms.