Why the study?
Do baseline cardiovascular indices (cardiac output, blood pressure variability) predict the rate of cognitive decline in ambulatory older adults with cardiovascular diseases?
Do baseline cardiovascular indices (cardiac output, blood pressure variability) predict the rate of cognitive decline in ambulatory older adults with cardiovascular diseases?
In older adults with cardiovascular disease, lower cardiac output and altered blood pressure variability are predictive of faster cognitive decline.
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These indices should not yet guide clinical decisions; hypothesis-generating for prospective trials on modifiable pathways.
Okonkwo et al. (2011) studied this question.
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