What does this research mean for the field?

A graded decrease in cardiac functioning is associated with features of brain aging in older adults. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 5, 2015Journal of the American Heart AssociationOpen Access

Cardiac Hemodynamics are Linked With Structural and Functional Features of Brain Aging: The Age, Gene/Environment Susceptibility (AGES)‐Reykjavik Study

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Key result

Lower LV stroke volume is linked to reduced total brain volume in older adults.

Why the study?

Is a graded decrease in cardiac hemodynamics (LVSV and CO) associated with structural and functional features of brain aging in community-dwelling older adults?

Population

931 community-dwelling older adults from the Age, Gene/Environment Susceptibility-Reykjavik Study in…

Design

Cohort

Authors

BSBehnam SabayanVascular Medicine MBMark A. van BuchemBoston University SSSigurður SigurdssonCardiac Imaging

Discussion

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Implication

Lower LVSV linked to smaller brain volumes in older adults without HF; hypothesis-generating and extends cardiac-brain aging observations.

Structured PICO

Is a graded decrease in cardiac hemodynamics (LVSV and CO) associated with structural and functional features of brain aging in community-dwelling older adults?

Population

931 community-dwelling older adults (mean age 75.9 years, 47.7% male) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study in Iceland. Key inclusion: free of contraindications for MRI scanning and gadolinium contrast injection.

Intervention

Cardiac hemodynamics assessment via MRI (specifically left ventricular stroke volume [LVSV] and cardiac output [CO])

Outcome

Structural and functional features of brain aging, specifically total parenchymal brain volume (TBV), gray matter volume (GMV), and cognitive performance (processing speed and executive function)surrogate

A graded decrease in cardiac functioning, even in community-dwelling older adults without advanced heart failure, is associated with structural brain aging and cognitive impairment.

Cite This Study

Sabayan et al. (2015) studied this question. Each 10 mL lower left ventricular stroke volume is associated with 4.4 mL lower total parenchymal brain volume in older adults.

synapsesocial.com/papers/6984fac3ff72350302d23f78 https://doi.org/10.1161/jaha.114.001294

Topics

HFrEF treatment Cardiac MRI Heart failure

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Implication

Lower LVSV linked to smaller brain volumes in older adults without HF; hypothesis-generating and extends cardiac-brain aging observations.

Cardiac Hemodynamics are Linked With Structural and Functional Features of Brain Aging: The Age, Gene/Environment Susceptibility (AGES)‐Reykjavik Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiac Hemodynamics are Linked With Structural and Functional Features of Brain Aging: The Age, Gene/Environment Susceptibility (AGES)‐Reykjavik Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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