What question did this study set out to answer?

This study aims to evaluate how well coronary calcifications can predict future cardiac events in asymptomatic diabetes mellitus patients.

October 10, 2008BMC Cardiovascular DisordersOpen Access

Predictive value of coronary calcifications for future cardiac events in asymptomatic patients with diabetes mellitus: A prospective study in 716 patients over 8 years

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Why the study?

Does coronary calcification assessment (Agatston score) improve the prediction of future cardiac death and myocardial infarction compared to traditional risk scores in asymptomatic patients with diabetes mellitus?

Population

716 asymptomatic patients with diabetes mellitus, no history of coronary artery disease, and no signs of CAD…

Comparison

Coronary calcification assessment using electron… vs Traditional clinical risk scores and lower…

Design

Cohort

Follow-up

mean 8.1+/-1.1 years

Authors

ABAlexander BeckerDüsseldorf University Hospital ALAlexander LeberDeutsches Herzzentrum der Charité CBChristoph R. BeckerCardiac Imaging

Discussion

Member takes

Implication

Agatston >400 may aid MI risk stratification in asymptomatic diabetes; leaves open prospective trials vs Framingham before guiding therapy.

Key Points

This study aims to evaluate how well coronary calcifications can predict future cardiac events in asymptomatic diabetes mellitus patients.
Prospective study over 8 years with 716 asymptomatic diabetes mellitus patients
Coronary calcifications assessed using electron beam computed tomography and Agatston score
Cardiac death and myocardial infarction rates were recorded after a mean follow-up of 8.1 years.
40 patients experienced myocardial infarction, and 36 died from cardiac death during follow-up.
Patients who suffered cardiac events had significantly higher initial Agatston scores (475±208) than those without (236±199, p<0.01).
An Agatston score above 400 corresponded with a higher annualized event rate for cardiovascular events (5.6% vs. 0.7%, p<0.01).

Structured PICO

Population

716 asymptomatic patients with diabetes mellitus, no history of coronary artery disease, and no signs of CAD on ECG, stress ECG, or echocardiography (mean age 55.2 years, 430 men)

Intervention

Coronary calcification assessment (Agatston score) using electron beam computed tomography

Comparator

Traditional clinical risk scores (Framingham risk score and UKPDS score) and lower Agatston score categories

Outcome

Cardiac death and myocardial infarctionhard clinical

Coronary artery calcium scoring provides superior risk stratification for future myocardial infarction and cardiac death compared to traditional clinical risk scores in asymptomatic patients with diabetes.

Cite This Study

Becker et al. (2008) studied this question.

synapsesocial.com/papers/6a701d28e5469ee92be0dfe9 https://doi.org/10.1186/1471-2261-8-27

Topics

Cardiomyopathy

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Implication

Agatston >400 may aid MI risk stratification in asymptomatic diabetes; leaves open prospective trials vs Framingham before guiding therapy.

Predictive value of coronary calcifications for future cardiac events in asymptomatic patients with diabetes mellitus: A prospective study in 716 patients over 8 years

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Predictive value of coronary calcifications for future cardiac events in asymptomatic patients with diabetes mellitus: A prospective study in 716 patients over 8 years

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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