Coronary artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis
Key result
A coronary artery calcium score ≥10 in type 2 diabetes predicted a higher risk of all-cause mortality or cardiovascular events compared to a score <10 (RR 5.47; 95% CI 2.59-11.53; P<0.001).
Why the study?
Does a coronary artery calcium score ≥ 10 predict all cause mortality or cardiovascular events in people with type 2 diabetes?
Population
8 prospective observational studies pooling 6,521 people with type 2 diabetes.
Comparison
Coronary artery calcium score ≥ 10 vs Coronary artery calcium score < 10
Design
Meta-analysis
Follow-up
mean 5.18 years
Authors
Discussion
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Implication
Supports CAC <10 to identify low-risk type 2 diabetes patients for stratification; confirms prognostic value in meta-analysis.
Study Design
Type
Meta-Analysis (n=6,521)
Structured PICO
Does a coronary artery calcium score ≥ 10 predict all cause mortality or cardiovascular events in people with type 2 diabetes?
P
Population
6,521 people with type 2 diabetes from 8 prospective studies, followed for a mean of 5.18 years.
E
Exposure
Coronary artery calcium score ≥ 10
C
Comparator
Coronary artery calcium score < 10
O
Outcome
All cause mortality or cardiovascular events (fatal and non-fatal)composite
Main Result
Relative Risk: 5.47 (95% CI 2.59–11.53)
p-value: p=<0.001
A coronary artery calcium score of <10 identifies a low-risk subgroup among people with type 2 diabetes, facilitating risk stratification.
Cite This Study
Kramer et al. (2013) conducted a meta-analysis in type 2 diabetes (n=6,521). Coronary artery calcium score ≥ 10 vs. Coronary artery calcium score < 10 was evaluated on all cause mortality or cardiovascular events, or both (RR 5.47, 95% CI 2.59 to 11.53, p=<0.001). A coronary artery calcium score ≥10 in type 2 diabetes predicted a higher risk of all-cause mortality or cardiovascular events compared to a score <10 (RR 5.47; 95% CI 2.59-11.53; P<0.001).