Population
Relaxed demembranated fibers from rabbit psoas muscle
Comparison
Temperature changes, lattice compression by 5%… vs Baseline or control conditions without…
Design
Preclinical
Authors
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Provides in situ myosin data in thick filaments; leaves open IHM exit mechanisms during activation.
In relaxed skeletal muscle at near-physiological temperature, most myosin heads are in interacting heads motif (IHM)-like conformations, which are absent during active contraction.
Fusi et al. (2015) studied this question.
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