May 6, 2013Proceedings of the National Academy of SciencesOpen Access

Structural basis of the relaxed state of a Ca 2+ -regulated myosin filament and its evolutionary implications

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Population

Ca2+-regulated (scallop) myosin filaments

Design

Preclinical

Authors

JWJohn L. WoodheadUniversity of Massachusetts Chan Medical School FZFa-Qing ZhaoNanchang University RCRoger CraigUMass Memorial Health Care

Discussion

Member takes

Implication

Supports conserved myosin off-switch across regulatory modes; hypothesis-generating for cardiac thick-filament studies.

Structured PICO

Population

Ca2+-regulated (scallop) myosin filaments

Intervention

Cryo-electron microscopy and single-particle image reconstruction

Outcome

Structural mechanism of myosin regulation in the relaxed state

The study provides structural evidence that Ca2+-regulated and phosphorylation-regulated myosin filaments share a common mechanism for switching off activity in relaxed muscle.

Cite This Study

Woodhead et al. (2013) studied this question.

synapsesocial.com/papers/6a701e3be5469ee92be0e14b https://doi.org/10.1073/pnas.1218462110

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Structural basis of the relaxed state of a Ca 2+ -regulated myosin filament and its evolutionary implications

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural basis of the relaxed state of a Ca 2+ -regulated myosin filament and its evolutionary implications

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider