Population
Myosin filaments isolated from scallop striated muscle
Comparison
Activation by calcium-containing solutions… vs Relaxed state (absence of calcium activation)
Design
Preclinical
Authors
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Calcium disrupts myosin order cooperatively in scallop muscle; leaves open whether intermolecular interactions regulate vertebrate cardiac activation.
Calcium binding disrupts the ordered helical arrangement of myosin projections in scallop striated muscle, suggesting intermolecular interactions maintain the relaxed state and propagate activation cooperatively.
Vibert et al. (1985) studied this question.
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