Why the study?
Do calcium-channel blockers reduce mortality, infarct size, and reinfarction rate in patients with acute myocardial infarction?
Do calcium-channel blockers reduce mortality, infarct size, and reinfarction rate in patients with acute myocardial infarction?
Diltiazem provides benefits in specific acute myocardial infarction patients (non-Q-wave or normal LV function), while nifedipine lacks benefit and may cause harm.
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May support diltiazem preference over nifedipine in select AMI subsets; leaves open need for contemporary RCTs.
Babich et al. (1989) studied this question.
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