Why the study?
Do calcium channel blockers improve chest pain in patients with mitral valve prolapse and coronary artery spasm?
Do calcium channel blockers improve chest pain in patients with mitral valve prolapse and coronary artery spasm?
Coronary artery spasm may be the underlying etiology of chest pain in some patients with mitral valve prolapse, suggesting calcium channel blockers may be an effective treatment while raising theoretical concerns against beta-blockade.
May support calcium channel blocker use for chest pain in mitral valve prolapse with spasm; hypothesis-generating and requires prospective trials.
The association between mitral valve prolapse (MVP) and atypical chest pain has been well-described. Numerous theories have been proposed to explain this association. A number of lines of evidence suggest that underlying ischemia may cause chest pain in some patients with MVP. We have recently evaluated 4 patients with chest pain syndromes who had angiographic evidence of MVP and spasm of angiographically normal coronary arteries. The possibility that coronary spasm is the underlying etiology of chest pain in some patients with mitral valve prolapse raises a theoretical argument against beta-blockade in these patients. Three of our patients were successfully treated with calcium channel blockers.
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Rippe et al. (1984) studied this question.
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