Why the study?
Does the AT(2) receptor antagonist PD123319 increase blood pressure in obese Zucker rats?
Population
Obese Zucker rats
Comparison
AT receptor antagonist PD123319 using osmotic… vs Age-matched lean rats and vehicle-treated obese…
Design
Preclinical
Follow-up
15 days
Authors
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AT2 blockade may worsen hypertension in obese models; leaves open renal AT2 protection in human obesity hypertension.
Does the AT(2) receptor antagonist PD123319 increase blood pressure in obese Zucker rats?
Renal AT2 receptors appear to protect against blood pressure increases in obesity, partly by suppressing kidney renin expression.
Siddiqui et al. (2008) studied this question.
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