What question did this study set out to answer?

This analysis aims to dissect the components of membrane currents in frog atrial muscle and explore their kinetics.

July 1, 1976The Journal of PhysiologyOpen Access

Analysis of pace‐maker and repolarization currents in frog atrial muscle.

View Full Paper

Ask AI

Bookmark

Population

Atrial wall trabeculae from Rana catesbeiana and Rana ridibunda

Design

Preclinical

Authors

HBHilary F. BrownUniversity of Oxford ACANNE CLARKHarvard University SNSusan NobleGoogle (United States)

Discussion

Member takes

Implication

Provides foundational kinetics for amphibian atrial currents; leaves open translation to mammalian repolarization or clinical use.

Key Points

This analysis aims to dissect the components of membrane currents in frog atrial muscle and explore their kinetics.
Used double sucrose gap technique for analysis.
Employed semilogarithmic method to separate conductance components ixfast and ixslow.
Investigated kinetics of outward currents over a wide potential range.
Different components of outward currents were effectively separated, showing distinct activation curves.
Inward-going rectification observed in the outward current systems.
Simplified analysis provided reliable representation of activation curves despite potassium accumulation.

Structured PICO

Population

Atrial wall trabeculae from Rana catesbeiana and Rana ridibunda

Intervention

Double sucrose gap technique and voltage clamp depolarizations

Outcome

Quantitative analysis of the time-dependent component of outward membrane current (ixfast, ixslow, and potassium accumulation)surrogate

This basic electrophysiology study characterizes the kinetic properties of outward membrane currents in frog atrial muscle, demonstrating the necessity of accounting for potassium ion accumulation when analyzing repolarization currents.

Cite This Study

Brown et al. (1976) studied this question.

synapsesocial.com/papers/6a701ee55d37378ac1dd2ef9 https://doi.org/10.1113/jphysiol.1976.sp011435

View Full Paper

Ask AI

Bookmark

Analysis of pace‐maker and repolarization currents in frog atrial muscle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Analysis of pace‐maker and repolarization currents in frog atrial muscle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider