November 12, 2004European Heart JournalOpen Access

Use of abciximab prior to primary angioplasty in STEMI results in early recanalization of the infarct-related artery and improved myocardial tissue reperfusion ? results of the Austrian multi-centre randomized ReoPro-BRIDGING Study

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Why the study?

Does early administration of abciximab during the organization phase for pPCI improve early reperfusion in patients with STEMI compared to administration immediately before pPCI?

Population

55 patients with ST-elevation myocardial infarction (STEMI)

Comparison

Abciximab started during the organization phase… vs Abciximab started immediately before pPCI

Design

RCT, randomized

Follow-up

7 days

Authors

MGMariann GyöngyösiInterventional Cardiology HDHans DomanovitsMedical University of Vienna WBWerner BenzerInterventional / Structural Cardiology

Discussion

Member takes

Implication

Supports early abciximab in STEMI to improve pre-pPCI reperfusion; extends evidence for upstream GP IIb/IIIa inhibition.

Structured PICO

Does early administration of abciximab during the organization phase for pPCI improve early reperfusion in patients with STEMI compared to administration immediately before pPCI?

Population

55 patients with ST-elevation myocardial infarction (STEMI)

Intervention

Abciximab (0.25 mg/kg bolus followed by 10 microg/min infusion) started during the organization phase for primary percutaneous coronary angioplasty (pPCI)

Comparator

Abciximab (0.25 mg/kg bolus followed by 10 microg/min infusion) started immediately before pPCI

Outcome

Early reperfusion assessed by pre-pPCI ST-segment resolution, TIMI flow grade 3, corrected TIMI frame count, %diameter stenosis, and myocardial tissue perfusionsurrogate

Early administration of abciximab during the organization phase for primary PCI in STEMI patients improves early recanalization and myocardial tissue reperfusion compared to administration immediately before the procedure.

Cite This Study

Gyöngyösi et al. (2004) studied this question.

synapsesocial.com/papers/6a701f595d37378ac1dd2fe2 https://doi.org/10.1016/j.ehj.2004.09.018

Topics

Dual antiplatelet therapy

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Use of abciximab prior to primary angioplasty in STEMI results in early recanalization of the infarct-related artery and improved myocardial tissue reperfusion ? results of the Austrian multi-centre randomized ReoPro-BRIDGING Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Use of abciximab prior to primary angioplasty in STEMI results in early recanalization of the infarct-related artery and improved myocardial tissue reperfusion ? results of the Austrian multi-centre randomized ReoPro-BRIDGING Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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