What question did this study set out to answer?

To determine whether ischemia induces the accumulation of lysophosphoglycerides in myocardium and evaluate their electrophysiological impact on cardiac conduction fibers.

September 1, 1978Journal of Clinical InvestigationOpen Access

Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium.

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Population

Isolated rabbit hearts and canine Purkinje fibers

Design

Preclinical

Authors

SBSobel BeWashington University in St. Louis PCPeter B. CorrElectrophysiology ARAlice K. RobisonTexas Medical Center

Discussion

Member takes

Implication

May implicate lysophosphoglycerides in ischemic arrhythmias; animal data leave open human relevance and therapeutic targeting.

Key Points

To determine whether ischemia induces the accumulation of lysophosphoglycerides in myocardium and evaluate their electrophysiological impact on cardiac conduction fibers.
Measured lysophosphoglyceride release and tissue accumulation in anoxic low-flow perfused rabbit hearts and in situ ischemic myocardium.
Assessed in vitro action potentials of isolated canine Purkinje fibers exposed to albumin-bound lysophosphoglycerides at concentrations matching ischemic tissue levels.
Lysophosphoglycerides accumulated markedly in ischemic myocardium and washed out into the effluent of low-flow anoxic hearts.
Albumin-bound lysophosphoglycerides reversibly reduced Purkinje fiber maximum diastolic potential, action potential duration, amplitude, and phase zero peak dV/dt.
Electrophysiological alterations replicated in vivo ischemic changes, creating conditions of slowed conduction that promote reentry-dependent dysrhythmias.

Structured PICO

Population

Isolated rabbit hearts and canine Purkinje fibers

Intervention

Ischemia (in rabbit hearts) and exposure to lysophosphoglycerides bound to albumin (in canine Purkinje fibers)

Outcome

Accumulation of lysophosphoglycerides and electrophysiological alterations (maximum diastolic potential, peak dV/dt of phase zero, amplitude, and action potential duration)surrogate

Accumulation of lysophosphoglycerides during ischemia may contribute to the genesis of malignant dysrhythmias by altering cellular electrophysiology.

Cite This Study

Be et al. (1978) studied this question.

synapsesocial.com/papers/6a701f69f44fa9f079ddab02 https://doi.org/10.1172/jci109159

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Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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