Key result
Lysophosphoglycerides (0.75-3.0 mM) induced concentration-dependent electrophysiological derangements in isolated canine Purkinje fibers, including decreased resting membrane potential and Vmax.
Population
Isolated canine Purkinje fibers and isolated rabbit papillary muscles
Comparison
Albumin-bound lysophosphatidyl choline and… vs Perfusion without LPC/LPE (baseline and washout)
Design
Preclinical
Authors
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May implicate lysophosphoglycerides in ischemic arrhythmias; leaves open translation from isolated fibers to intact hearts or patients.
Lysophosphoglycerides induce arrhythmogenic electrophysiological alterations in isolated cardiac tissues, suggesting a biochemical mechanism for ischemia-induced malignant dysrhythmias.
Corr et al. (1979) studied Myocardial ischemia (experimental model). Lysophosphoglycerides (LPC and LPE) vs. Baseline/perfusion without LPC was evaluated on Electrophysiological alterations (resting membrane potential, Vmax, action potential duration, conduction time). Lysophosphoglycerides (0.75-3.0 mM) induced concentration-dependent electrophysiological derangements in isolated canine Purkinje fibers, including decreased resting membrane potential and Vmax.
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