July 1, 2001Journal of Neurophysiology

Identification of Two Types of Inspiratory Pacemaker Neurons in the Isolated Respiratory Neural Network of Mice

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Population

Isolated respiratory neural network in transverse brain stem slices containing the pre-Bötzinger complex…

Design

Preclinical

Authors

MTMuriel Thoby‐BrissonCentre National de la Recherche Scientifique JRJan‐Marino RamirezRush University Medical Center

Discussion

Member takes

Implication

Distinguishes two inspiratory pacemaker subtypes in mice; leaves open their roles in rhythmogenesis and any translational relevance.

Structured PICO

Population

Isolated respiratory neural network in transverse brain stem slices containing the pre-Bötzinger complex (PBC) from mice (n=52 inspiratory neurons)

Intervention

Whole cell patch-clamp technique with blockade of respiratory network activity using 6-cyano-7-nitroquinoxalene-2,3-dione (CNQX), and application of cadmium or tetrodotoxin

Outcome

Pacemaker properties including burst duration, frequency, and response to cadmium and tetrodotoxin

The respiratory neural network in mice contains at least two distinct types of inspiratory pacemaker neurons with different bursting properties and pharmacological sensitivities.

Cite This Study

Thoby‐Brisson et al. (2001) studied this question.

synapsesocial.com/papers/6a701fbb660549caf2c4aed3 https://doi.org/10.1152/jn.2001.86.1.104

View Full Paper

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Identification of Two Types of Inspiratory Pacemaker Neurons in the Isolated Respiratory Neural Network of Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of Two Types of Inspiratory Pacemaker Neurons in the Isolated Respiratory Neural Network of Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider