Population
Rhythmically active slices containing the pre-Bötzinger complex (n=72 experiments)
Design
Preclinical
Authors
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Challenges fixed pacemaker models of breathing in animals; leaves open stochastic network mechanisms for future validation.
Pacemaker neurons in the respiratory network do not act as clock-like drivers but play a flexible, dynamic role in burst initiation, suggesting each breath is a de novo assembly of stochastic collaboration.
Carroll et al. (2012) studied this question.
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