Key result
A dual oscillator computational model demonstrated that quantal slowing of the respiratory rhythm can occur due to a breakdown of synchronized bursting within the preBötzinger complex, without requiring stochastic synaptic transmission.
Population
Computational dual oscillator model of the respiratory neuronal network, comprising the parafacial…
Design
Preclinical
Authors
Loading...
Challenges stochastic transmission requirement for quantal slowing; leaves open in vivo validation of synchronized bursting breakdown.
This computational model suggests that quantal slowing in respiratory rhythms can result from a breakdown of synchronized bursting within the preBötC, challenging previous hypotheses requiring stochastic synaptic transmission.
Lal et al. (2010) studied Respiratory rhythm generation (computational model). Dual oscillator computational model was evaluated. A dual oscillator computational model demonstrated that quantal slowing of the respiratory rhythm can occur due to a breakdown of synchronized bursting within the preBötzinger complex, without requiring stochastic synaptic transmission.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: