Key result
Computational models of respiratory neurons showed that a frequency ramp firing pattern can result from intrinsic membrane properties, specifically K(AHP)(Ca), low-threshold Ca(T) and K(A) channels.
Population
Computational models of single mammalian brain stem respiratory neurons (Hodgkin-Huxley style)
Design
Preclinical
Authors
Loading...
May inform respiratory neuron models; leaves open whether Ca channel ratios shape breathing patterns in vivo.
Computational modeling of respiratory neurons suggests that the ratio of Ca(L) to Ca(T) channels dictates whether neurons exhibit adapting or ramp firing patterns.
Rybak et al. (1997) studied Respiratory rhythm genesis. Computational modeling was evaluated on Firing patterns of respiratory neurons. Computational models of respiratory neurons showed that a frequency ramp firing pattern can result from intrinsic membrane properties, specifically K(AHP)(Ca), low-threshold Ca(T) and K(A) channels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: