Key result
A computational model of the pre-Bötzinger complex reveals that rhythm generation is independent of ICAN activation, which instead determines population activity amplitude.
Population
Computational model of an excitatory population of 100 neurons in the mammalian brainstem pre-Bötzinger…
Design
Preclinical
Authors
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Distinguishes rhythm from amplitude mechanisms in respiratory models; leaves open in vivo relevance for breathing control.
This computational model demonstrates that in the mammalian respiratory oscillator, rhythm generation and amplitude involve distinct biophysical mechanisms, with rhythm depending on INaP and amplitude determined by ICAN.
Phillips et al. (2018) studied Respiratory rhythm generation. Computational modeling of ICAN and INaP conductances was evaluated. A computational model of the pre-Bötzinger complex reveals that rhythm generation is independent of ICAN activation, which instead determines population activity amplitude.
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