Population
Cells transfected with synthetic nonreplicable subgenomic transcripts derived from bovine viral diarrhea virus
Comparison
Modification of the 5' triphosphates and 3'… vs Unmodified RNA molecules
Design
Preclinical
Authors
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Supports RNA recombination via end modifications in animal cells; leaves open relevance to human viral pathogenesis or therapies.
The study provides evidence supporting the hypothesis that endoribonucleolytic cleavage and subsequent ligation can cause RNA recombination in living cells.
Austermann-Busch et al. (2012) studied this question.
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