Why the study?
Does enflurane compared with isoflurane anaesthesia increase serum fluoride levels in morbidly obese patients undergoing gastroplasty?
Does enflurane compared with isoflurane anaesthesia increase serum fluoride levels in morbidly obese patients undergoing gastroplasty?
Enflurane anaesthesia results in significantly higher peak serum fluoride concentrations compared to isoflurane in morbidly obese patients.
Enflurane was associated with higher fluoride levels than isoflurane in obese patients; leaves open clinical relevance and should not yet change practice.
Obese patients are known to metabolise anaesthetic agents more than patients of normal weight. The extent of this was investigated by the measurement of serum fluoride concentrations in 10 morbidly obese patients undergoing gastroplasty. Five were allocated to receive enflurane and five to receive isoflurane supplemented anaesthesia. The mean peak serum fluoride concentrations after enflurane anaesthesia were greater (22.7 mumol/litre, SE 2.9) than after isoflurane anaesthesia (6.5 mumol/litre, SE 0.6). The mechanisms and implications of this finding are discussed.
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Strube et al. (1987) studied this question.
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