Why the study?
Does enflurane anesthesia lead to toxic serum inorganic fluoride levels in patients?
Does enflurane anesthesia lead to toxic serum inorganic fluoride levels in patients?
Enflurane anesthesia does not typically produce toxic levels of inorganic fluoride, suggesting a low risk of polyuric renal failure.
Suggests low nephrotoxicity risk after enflurane; leaves open confirmation in prospective trials of high-risk patients.
Early observations with enflurane indicated that this drug was biotransformed in man to inorganic fluoride. In the present study, 102 patients in three groups were exposed to enflurane anesthesia and serial serum inorganic fluoride levels measured. Group I patients were A.S.A. status I or II, without pertinent medical or anesthetic history. Group II was similar except for one previous enflurane anesthetic. Group III was also similar except all patients had been taking barbiturates before enflurane anesthesia. Inorganic fluoride was found to be a product of the biotransformation of enflurane; however, postoperative serum levels were rarely above 50 micromols/L. It is concluded that polyuric renal failure from inorganic fluoride toxicity is not likely to follow enflurane anesthesia.
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Albert L. Maduska (1974) studied this question.
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