Temporal Trends in Patient Characteristics and Treatment With Intravenous Thrombolysis Among Acute Ischemic Stroke Patients at Get With the Guidelines–Stroke Hospitals
Why the study?
How have the rates of intravenous tPA use and patient characteristics changed over time among acute ischemic stroke patients?
Population
1,093,895 acute ischemic stroke patients, including 50,798 arriving ≤ 2 hours and treated with tPA ≤ 3 hours…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Increased tPA use in AIS was observed over time; extends prior trends but leaves open drivers and outcome impact.
Structured PICO
How have the rates of intravenous tPA use and patient characteristics changed over time among acute ischemic stroke patients?
P
Population
1,093,895 acute ischemic stroke (AIS) patients, including 50,798 arriving ≤ 2 hours and treated with tPA ≤ 3 hours after onset, from 2003 to 2011 in the American Heart Association's Get with the Guideline-Stroke (GWTG-Stroke) registry.
I
Intervention
Intravenous tissue plasminogen activator (tPA) administration
O
Outcome
Rates of intravenous tPA use and changes in patient characteristics over time
The use of IV tPA for acute ischemic stroke significantly increased from 2003 to 2011, with expanded use in older, nonwhite patients and those with milder strokes.
Cite This Study
Schwamm et al. (2013) studied this question.