Why the study?
Does bone marrow c-kit function impact myocardial healing and cardiac remodeling after myocardial infarction in mice?
Population
Kit/Kit c-kit mutant mice and their wild-type littermates subjected to coronary ligation
Comparison
c-kit mutation and wild-type bone marrow… vs Wild-type littermates
Design
Preclinical
Follow-up
up to 14 days
Authors
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c-kit+ bone marrow cells may limit adverse remodeling after MI in mice; leaves open whether c-kit pathways warrant targeting in patients.
Does bone marrow c-kit function impact myocardial healing and cardiac remodeling after myocardial infarction in mice?
Bone marrow c-kit function is critical for the myofibroblast repair response and prevention of infarct expansion after myocardial infarction in a mouse model.
Cimini et al. (2007) studied this question.
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