October 9, 2009BMC Cardiovascular DisordersOpen Access

Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy

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Population

23 dogs (8 with healed myocardial infarction, 8 after 7 weeks of overpacing, 7 healthy controls)

Comparison

Induction of ischemic cardiomyopathy or… vs Healthy control dogs

Design

Preclinical

Follow-up

7 weeks for overpacing group

Authors

MMMaryam MahmoudabadyMashhad University of Medical Sciences MMMyrielle MathieuUniversité Libre de Bruxelles KTKarim TouihriCentre Hospitalier Interrégional Edith Cavell

Discussion

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Implication

Differential IGF-1 signaling in canine models; leaves open distinct drivers of hypertrophy versus dilation for human study.

Structured PICO

Population

23 dogs (8 with healed myocardial infarction, 8 after 7 weeks of overpacing, 7 healthy controls)

Intervention

Induction of ischemic cardiomyopathy (myocardial infarction) or tachycardiomyopathy (overpacing)

Comparator

Healthy control dogs

Outcome

Myocardial gene expressions of IGF-1, IGF-1R, TGFbeta, and cyclins A, B, D1, D2, D3, and E, and echocardiographic parameterssurrogate

IGF-1/IGF-1R and cyclins appear to be involved in the hypertrophic response observed in ischemic cardiomyopathy but not in the dilation seen in tachycardiomyopathy in canine models.

Cite This Study

Mahmoudabady et al. (2009) studied this question.

synapsesocial.com/papers/6a702773ce524a4339c3ecee https://doi.org/10.1186/1471-2261-9-49

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Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac insulin-like growth factor-1 and cyclins gene expression in canine models of ischemic or overpacing cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider