June 15, 1987FEBS Letters

Internal perfusion of guinea‐pig hepatocytes with buffered Ca2+ or inositol 1,4,5‐trisphosphate mimics noradrenaline activation of K+ and Cl− conductances

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Population

Guinea-pig isolated hepatocytes

Design

Preclinical

Authors

TCThierry CapiodDélégation Paris 5 AFA C FieldAustralian National University DOD. C. OgdenAmazon (United Kingdom)

Discussion

Member takes

Implication

Provides mechanistic clues for noradrenaline signaling in hepatocytes; leaves open relevance to cardiovascular cell types.

Structured PICO

Population

Guinea-pig isolated hepatocytes

Intervention

Internal perfusion with 2 microM buffered Ca2+ or 20 microM inositol 1,4,5-trisphosphate (IP3), and external application of noradrenaline

Outcome

Membrane conductance increases to K+ and Cl-surrogate

In guinea-pig hepatocytes, internal IP3 mimics noradrenaline-induced cyclical conductance fluctuations, suggesting intracellular Ca2+ oscillations arise from sequestration mechanisms at constant IP3 levels.

Cite This Study

Capiod et al. (1987) studied this question.

synapsesocial.com/papers/6a7027763ce530166bc2bf82 https://doi.org/10.1016/0014-5793(87)80672-5

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Internal perfusion of guinea‐pig hepatocytes with buffered Ca2+ or inositol 1,4,5‐trisphosphate mimics noradrenaline activation of K+ and Cl− conductances

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Internal perfusion of guinea‐pig hepatocytes with buffered Ca2+ or inositol 1,4,5‐trisphosphate mimics noradrenaline activation of K+ and Cl− conductances

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider