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July 1, 1979The Journal of PhysiologyOpen Access

Influence of potassium, sodium, perfusion pressure, and isoprenaline on renin release induced by acute calcium deprivation

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Population

Isolated perfused rat kidneys

Comparison

Acute calcium deprivation with varying perfusion… vs Control perfusion medium

Design

Preclinical

Follow-up

10 min (acute)

Authors

JFJ. C. FrayWorcester Polytechnic InstituteCPC. S. ParkUniversity of California, San Francisco

Discussion

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Implication

Animal data bolster calcium's role in renin control; hypothesis-generating and leaves open human relevance.

Structured PICO

P
Population
Isolated perfused rat kidneys
I
Intervention
Acute calcium deprivation (0-2.5 mM Ca) with varying perfusion pressure (50-150 mmHg), isoprenaline (2.43 muM), potassium, and sodium (25-145 mM) concentrations
C
Comparator
Control perfusion medium (normal calcium, normal pressure, etc.)
O
Outcome
Renin releasesurrogate

These findings support the hypothesis that decreased cytoplasmic calcium in juxtaglomerular cells stimulates renin release, modulated by perfusion pressure, membrane potential, and Ca-Na exchange.

Cite This Study

Fray et al. (1979) studied this question.

synapsesocial.com/papers/6a7027763ce530166bc2bf96https://doi.org/10.1113/jphysiol.1979.sp012856
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulation of renin secretion and calcium efflux from the isolated perfused cat kidney by noradrenaline after prolonged calcium deprivation.1978 · 24 citations
  2. 2A study of releasable Ca fractions in smooth muscle cells of the rabbit aorta.1977 · 137 citations
  3. 3The dependence of calcium efflux from cardiac muscle on temperature and external ion composition1968 · 1,025 citations
  4. 4Na—Ca exchange and tension development in arterial smooth muscle1973 · 301 citations
  5. 5Calcium‐sodium antagonism on the frog's heart: a voltage‐clamp study.1976 · 63 citations